Webb什么是CreERT2 ?. 将人雌激素受体(estrogen receptor,简称ER)的配体结合区(LBD)与Cre 重组酶相融合,形成定位于胞浆中的融合蛋白(Cre-ER)。. 只有在雌激 … Webb一、品系介绍:. Cre-ERT2小鼠是一类含有雌激素受体(estrogen receptor,ER)的配体结合区突变体(ERT)与Cre重组酶的融合蛋白表达的小鼠。. Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与 ...
Prox1 postmitotically defines dentate gyrus cells by specifying …
WebbCre 重组酶基因编码区序列全长1029bp,编码 38kDa 蛋白质,Cre 重组酶是由 343 个氨基酸组成的单体蛋白。. LoxP 位点,是 locus of X-over P1的缩写,是位于 P1 噬菌体中的 … http://www.labmodel.cn/mod_product-view-p_id-4659.html broadway in boston season tickets
Prox1-CreERT2 PCR Vascular Development Lab - Taija Makinen
Webb1 jan. 2024 · Prox1-CreERT2 Hk2 fl/fl mice also phenocopied Fgfr1/3 mutant mice (Yu et al., 2024). Ultimately, Fgfr-regulated Myc binds to regulatory elements of the Hk2 gene and … WebbTg (Prrx1-cre/ERT2,-EGFP)1Smkm. Mutation details : The cre/ER T2 cDNA was cloned downstream of a 2.4 kb Prrx1 promoter. cDNA encoding an IRES-EGFP was inserted … Webb21 nov. 2016 · Prox1 CreERT2. Prox1 is a transcription factor that is expressed in IPCs, OPCs, and DCs throughout the neonatal organ of Corti but is downregulated by ∼P14 (Bermingham-McDonogh et al. 2006). The Prox1 CreERT2 mouse line is a knock-in allele, where CreER was inserted into the endogenous Prox1 locus (Srinivasan et al. 2007). broadway in boston subscriber login