WebAn Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes WebMay 16, 2011 · Longer is better: Polytheonamide B, the largest nonribosomal linear peptide identified to date, is a transmembrane channel‐forming peptide. Nine of its substructures have now been chemically synthesized. The membrane‐disrupting and ion‐channel‐forming sequences as well as the cytotoxicity‐enhancing sequence have been identified.
Polytheonamide biosynthesis showcasing the metabolic potential …
WebBGC0000598: polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. WebMar 6, 2024 · Polytheonamide B (1) is an exceptionally large peptide that forms a transmembrane ion channel.The potent cytotoxicity of 1 against MCF-7 cancer cells … convert large tiff to pdf
Functional Analysis of Synthetic Substructures of Polytheonamide …
WebA prominent example is polytheonamide A, which exhibits numerous post-translational modifications, some of which were unknown in ribosomal peptides until recently. Among these post-translational modifications, C-methylations have been proposed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC. WebPolytheonamide B (1) is a natural peptide that displays potent cytotoxicity against P388 mouse leukemia cells (IC 50 =0.098 n m).Linear 48-mer 1 is known to form monovalent … WebSep 9, 2024 · The host generates polytheonamide-like compounds within 2 days, and can efficiently introduce multiple d-amino acids, asparagine N-methylations and C-methyl … fall upcoming events