Phosgene is an insidious poison as the odor may not be noticed and symptoms may be slow to appear. The odor detection threshold for phosgene is 0.4 ppm, four times the threshold limit value. Its high toxicity arises from the action of the phosgene on the –OH, –NH2 and –SH groups of the proteins in pulmonary alveoli (the site of gas exchange), respectively forming ester, amide and thioester fu… WebDec 1, 2013 · Background. Pulmonary agents (also known as "choking" agents) compose a class of chemical compounds that disrupt normal breathing. They encompass a wide array of gases, including chlorine, ammonia, phosgene, organohalides, and nitrogen oxides. 1,2 These compounds have figured prominently in military conflicts; notably, the US Civil War, …
Vesicant Chemical-Warfare Agents - Injuries; Poisoning - Merck …
WebPhosgene (Carbonyl Chloride, COCl2) remains an important chemical intermediate in many industrial processes such as combustion of chlorinated hydrocarbons and synthesis of solvents (degreasers, clean smart chevrolet finance apply for financing
Continuous positive airway pressure: An early ... - ScienceDirect
WebPhosgene is classified as a chemical warfare agent, yet data on its short-duration high concentration toxicity in a nose-only exposure rat model is sparse and inconsistent. Hence, an exposure system for short-term/high concentration … WebPhosgene-induced ALI showed evidence of persistent apnea periods, bradycardia, and shifts of vascular fluid from the peripheral to the pulmonary circulation. Carbon dioxide … Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine Webimmediately or shortly after exposure to Phosgene: * Contact can severely irritate and burn the skin and eyes. * Breathing Phosgene can irritate the nose and throat. * Breathing Phosgene can irritate the lungs causing coughing and/or shortness of breath. Higher exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical hillbilly blood chords