WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ... WebCyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules and improve their …
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WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for … WebJan 5, 2011 · Phase-solubility study was carried out according to the method of Higuchi and Connors [ 19 ]. Excess amount of repaglinide (approx. 10 mg) was added to 2.5 mL 10 mM phosphate buffer (pH 6 and pH 3.5) containing increasing amounts of Captisol ® (10 −3 –10 −1 M) and shaken at 25 ± 0.5 °C.
WebThe CAT content in the supernatant was analyzed using a UV-visible spectrophotometer (UV-2550, Shimadzu, Japan) at 230 nm. All experiments were performed in triplicate. The apparent stability constant (K C) was calculated using Higuchi-Connors equation based on the straight-line part of the phase solubility diagram: (1) K C = s l o p e S 0 × 1 ... WebHiguchi (樋口, literally "mouth of the drain") is a common Japanese surname. People with the surname. Akihiro Higuchi, Ukrainian-born film director known by his alias Higuchinsky; …
WebHiguchi, T., Connors, K.A., Phase-solubility techniques, Adv. Anal. Inst., 4, 117–212 (1965) Google Scholar Higuchi, T., Kristiansen, H., J ., Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies, Pharm. Sci., 59, 1601–1608 (1970) Google Scholar WebMay 31, 1995 · Eliteprospects.com hockey player profile of Connor Hutchins, 1995-05-31 North Richland Hills, TX, USA USA. Most recently in the SPHL with Peoria Rivermen. …
WebThe Higuchi–Connors phase diagram indicated the formation of weak 1:1 and 1:2 complexes. In addition, the reaction conditions were applied to poly (vinylimidazole) and 1,4-bis (1 H -imidazol-1-yl)butane to obtain functionalized polymer networks and oligomers, which were stable at temperatures up to 300 °C and 200 °C, respectively. Experimental
WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization ireland squad new zealandWebApr 27, 2016 · The plateau and decrease of ADPA content in the Higuchi–Connors diagram are caused by the limited solubility of the inclusion complex and its precipitation from the saturated solution, correspondingly. According to the classification of Higuchi and Connors [ 37 ], the phase solubility diagram obtained at pH = 5.00 belongs to B S type. ireland sports jobsWebTeam Date Transaction; March 24, 2024: Amarillo Sod Poodles released LHP Connor Higgins. January 25, 2024: LHP Connor Higgins assigned to Amarillo Sod Poodles. ireland st brigid\u0027s dayWebApr 16, 2004 · Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined. ireland standard tax ratesWebAug 28, 2024 · The Higuchi-Connors method was used to corroborate it. The Benesi-Hildebrand method fixes ligand concentration (cyclodextrin) to different solutions with variable amounts of the substrate, from one to five mM. The absorbance of the free ligand is measured, and then subtracted from the rest of the solution's absorbances levels (ΔA). ireland standard rate bandWebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug... ireland stapleton pryor \u0026 pascoeWebHiguchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article Solid Dispersion Incorporated … ireland st. stephen\u0027s day