WebCluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 ( CD40L) on T H cells to CD40 activates antigen presenting cells and induces a … WebCD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production, and isotype switching. CD40-CD40L …
Functional CD40 ligand is expressed on human vascular ... - PNAS
WebCD40 Ligand (CD40L), also known as CD154, TRAP, or gp39, is a type II transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) family. It is mainly expressed in CD4+-T cells and interacts with CD40 on … Webtion in CD28–/– mice indicates that its function is at least partially CD28-independent. Consistent with this observation, ... CD40 ligand on human CD4„ T lymphocytes generates a costimu- ... graft rejection by blockade of the CD40-gp39 pathway. Transplan-tation 1996; 61: 4. 18. Wekerle T, Sayegh MH, Hill J et al. Extrathymic T cell ... event tourney smash
Functions of CD40 and its ligand, gp39 (CD40L). - Europe …
WebThe CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells. WebCD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity. WebCD40L (CD154, gp39) (TNFSF5) T and B cells, endothelium ... Its ligand, 4-1BBL, is found on mature dendritic cells (DCs), activated B cells, and activated macrophages. The distribution of this pairing as well as the inducible nature of their expression suggest that this molecular pathway may have an important regulatory role in immune responses ... event tracer handball4all