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Epcam biology

WebMay 31, 2024 · EpCAM (CD326) is a conserved type I transmembrane glycoprotein of 35 kDa expressed on epithelial cells of higher eukaryotes. It was initially discovered as a … WebThe epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. ... Here, we provide a comprehensive review of the current knowledge on EpCAM biology in relation to ...

Biology and clinical relevance of EpCAM - PubMed

WebEpithelial Cell Adhesion Molecule. The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein which is typically expressed by cancers originating from epithelial tissue [94–97], and not expressed in hematological cells. From: Advances in Clinical Chemistry, 2024. Related terms: T Cell; Cancer Stem Cell; CD44; CD133 WebMay 12, 2024 · EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling … cu(no3)2 kno3 용해도 https://dcmarketplace.net

Epithelial Cell Adhesion Molecule - an overview - ScienceDirect

WebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … WebNov 24, 2024 · Ep-CAM: a human epithelial antigen is a homophilic cell–cell adhesion molecule. J. Cell Biol. 1994;125 (2):437-446. Article CAS Google Scholar Trzpis M, McLaughlin PM, de Leij LM, Harmsen MC. Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am. J. Pathol. 2007;171 (2):386-395. Article … WebApr 4, 2024 · Journal Metrics. Communications Biology has a 2-year impact factor: 6.548 (2024), article downloads of 4,666,583 (2024) and 11 days from submission to the first editorial decision. الهه از خون جوانان وطن لاله دمیده

EpCAM and the biology of hepatic stem/progenitor cells

Category:Biology and clinical relevance of EpCAM - PMC

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Epcam biology

Crystal structure and its bearing towards an understanding of …

WebMay 21, 2024 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM … WebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells …

Epcam biology

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WebAug 1, 2013 · EpCAM is a cell surface glycoprotein of approximately 40 kDa (detailed below) that is highly expressed in epithelial cancers and at lower levels in normal simple … WebMay 31, 2024 · EpCAM (CD326) is a conserved type I transmembrane glycoprotein of 35 kDa expressed on epithelial cells of higher eukaryotes. It was initially discovered as a …

WebAug 5, 2024 · The biology of EpCAM and its role are not completely understood but evidence suggests that the expression of this epithelial cell-surface protein is crucial for metastasis-competent CTCs and may not be lost completely during the epithelial-to-mesenchymal transition. In this review, we summarize the most significant advantages … Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more

WebStreptavidin-PE was used to place all the lineage marker-positive cells in the PE channel, and EpCAM-APC was used to stain all epithelial cells. At the same time, cells were stained with Annexin V and 7-amino-actinomycin D (7-AAD, PE Annexin V Apoptosis Detection Kit I, BD Biosciences) according to the manufacturer's instructions. WebThe epithelial cell adhesion molecule (EpCAM, also designated TACSTD1, CD326) is a type I transmembrane protein of 314 ... Taken together, these studies suggest that the impact of EpCAM expression on cancer biology may be context-dependent (reviewed in van der Gun et al, 2010). Breast cancer is a heterogeneous disease. Recent advances in

Webof EpCAM expression with prognosis in different cancers is supported by functional studies of EpCAM biology using in vitro and in vivo cancer models as well. Taken together these studies suggest that the impact of EpCAM expres-sion in human cancers is likely to be context dependent [28]. EpCAM expression based assay has been FDA ap-

WebFeb 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is expressed at the basolateral membrane of most normal epithelial cells but is overexpressed in many epithelial cancers. الهه ای که رفته با خودcuore prevod na hrvatskiWebFeb 13, 2024 · Epithelial–mesenchymal transition (EMT) is an important biological process that has been implicated in cancer metastasis. Epithelial cell adhesion molecule (EpCAM) is expressed at the ... الهه اشور