WebJun 3, 2024 · At the clinical cutoff (June 19, 2024), 461 patients (85%) in the D-VTd group and 437 patients (81%) in the VTd group completed all four induction and both consolidation cycles, and 489 patients (90%) and 484 patients (89%) had undergone autologous stem-cell transplantation ( figure 1 ). WebSep 27, 2024 · Treatment with DVTd resulted in a reduction in the risk of progression or death by 53 percent compared to VTd alone (HR=0.47; 95 percent CI: 0.33, 0.67; p<0.0001).The sCR rate at Day 100 post-ASCT was 28.9 percent in the DVTd arm and 20.3 percent in the VTd arm. Adverse reactions with daratumumab
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WebDVTd versus VTd – In another trial (CASSIOPEIA), 1085 patients with newly diagnosed MM eligible for HCT were randomly assigned to receive induction with four cycles of bortezomib, thalidomide, and dexamethasone with or without daratumumab (DVTd versus VTd), followed by autologous HCT plus two cycles of consolidation with the assigned … WebAug 14, 2024 · VTD induction consisted of bortezomib 1.3 mg/m 2 SC (day 1, 4, 8,and 11), thalidomide 100 mg/day, and dexamethasone 20 mg (day 1–2, 8–9, J15–16, and 22–23) (28-day cycle). VRD induction... can beverly be a man\\u0027s name
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WebDRAFT Presented at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition; December 11-14, 2024; Atlanta, GA/Virtual CASSIOPEIA: D-VTd Improved Rates of ≥CR + MRD Negativity (MFC; 10–5) Versus VTd Following Induction and Consolidation 9.2 33.7 5.4 19.9 0 10 20 30 40 50 60 70 Post induction Post … WebSep 21, 2024 · The interaction between induction and consolidation and maintenance was tested at a two-sided significance level of 0·05 by a stratified Cox regression … WebDec 11, 2024 · In part 1 of CASSIOPEIA, D-VTd induction therapy prolonged progression-free survival (PFS) and improved depth of response for patients, which included … can be used to assay motility