Ctgf and cyr61
WebApr 12, 2024 · The volcano plot revealed a significant increase in the expression of CTGF and CYR61 downstream of YAP as a result of USP1 depletion. Threshold values of P < … WebJun 26, 2024 · As a secreted protein, CTGF exerts autocrine and paracrine actions because it localizes not only within the interstitial ECM but also pericellularly, due to its heparin-binding activity (Kireeva et al., 1997).To gain new insights into the function of vascular cell-derived CTGF, we examined the retinal vascular changes associated with global, EC-, or …
Ctgf and cyr61
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WebNov 21, 2024 · RASSF1A is a tumor suppressor gene, and its hypermethylation has been observed in cancers. RASSF1A acts as an upstream regulator of Hippo pathway and modulates its function. The aim of this study was to analyze expression of RASSF1A, Hippo pathway molecules (YAP, MST) and downstream targets (CTGF, Cyr61 and AREG) in … WebSeveral studies have shown that CYR61 and CTGF are direct targets of YAP and TAZ [17,86,87,169]. These observations suggest that antagonizing the activity of CYR61 and CTGF could be a potential approach to treat YAP- and TAZ-dependent tumors.
WebJun 1, 2024 · Mechanistically, CTGF and Cyr61 downregulated ERα expression at the transcriptional level by directly binding to the regulatory regions of the ERα-encoding … WebDownload scientific diagram YAP1 targets CYR61 and connective tissue growth factor (CTGF) expression and secretion are regulated by BMP9 and endoglin. All cells were …
WebJun 9, 2024 · At the same time, the mRNA levels of the YAP-TEAD downstream genes CTGF and CYR61 decreased. Moreover, in a xenograft model derived from GC patients, VP reduces YAP-TEAD transcription activity, inhibits the proliferation of gastric cancer stem cells (CSC), and inhibits the growth of GC in vivo. WebAug 1, 1997 · The cysteine-rich secreted protein Cyr61 was the first member of the CTGF gene family to be identified. This protein, originally known as 3CH61, was isolated by Lau and Nathans 1 in 1985 from mouse fibroblasts stimulated with serum and PDGF. Eleven years later, seven related proteins, including the chicken ortholog for Cyr61, CEF10 2; …
WebThe penile expression levels of YAP, TAZ, CTGF, and CYR61 were significantly downregulated in the BCNI group (p<0.01), and LIPUS upregulated the expression levels of these proteins (p<0.05). The expression levels of p-LATS1 and LATS1 were not significantly different among the groups (p>0.05). Interestingly, the expression level of p-p38/p38 ...
WebJun 20, 2007 · Expression patterns of Cyr61, CTGF, and WISP-1 protein in NSCLC and matched normal lung tissues. The graph depict distributions of specimens according to … graber accents sliding panel shadesWebNational Center for Biotechnology Information graber and companyWebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). The term ‘connective tissue growth factor ... graber ace hardware newtonWebJun 20, 2007 · Our results suggest that Cyr61, CTGF, and WISP-1might be implicated in the development and progression of primary lung cancers, and their levels might serve as valuable prognostic markers, as well as potential targets for therapeutic intervention. Introduction Lung cancer is the most common cause of cancer death in the world [1]. graber agencyWebSep 23, 2016 · The results showed that the mRNA levels of YAP, CTGF, and CYR61 were downregulated upon treatment with resveratrol (50 μM) (Figure 3C,D). Additionally, the nuclear translocation of YAP was decreased due to the effect of resveratrol, as demonstrated by immunofluorescence (Figure 3E). Together, these data indicate that … graber ace hardwareWebIt has been reported that CYR61 and CTGF were target genes of TGF-β.21,22 To examine whether this is the same case in ESCC cells, we treated EC109 cells with TGF-β1, and … graber andreas sigriswilWebApr 1, 2024 · Human polyclonal anti-rabbit CYR61, CTGF, and dCK antibodies and polyclonal goat anti-rabbit IgG-HRP and monoclonal goat anti-mouse IgG-HRP were … graber andreas