Cisplatin hearing loss thesis

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August undefined, 2024

WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... WebJun 3, 2024 · The topic of my MSc thesis work was “Synthesis and Characterization of CuO-PVA Nanofluid for Heat Transfer Applications”. ... Cisplatin-induced ototoxicity (CIO), manifests as permanent, bilateral, high frequency sensorineural hearing loss that is estimated to affect 26-90% of children that has debilitating effects on children’s ...

Potential Cause of Cisplatin-Linked Hearing Loss Identified

WebCISPLATIN-INDUCED HEARING LOSS IN CHOP KO MICE 2 Abstract Cisplatin is a chemotherapeutic drug that causes hearing loss, and the mechanisms of its ototoxicity … WebCisplatin may cause serious hearing problems, especially in children. Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking ... iowa state football nfl combine

Cisplatin-Induced Hearing Loss - Fennec Pharmaceuticals

WebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely. WebThis thesis is based on the following original papers, which will be referred to in the text by their Roman numerals I-V. Ekborn A, Laurell G, Andersson A, Wallin I, Eksborg S, Ehrsson H. Cisplatin-induced hearing loss: influence of the mode of drug administration in the guinea pig. Hear Res 2000;140(1-2):38-44. opengl drawarrays

Atorvastatin is associated with reduced cisplatin-induced hearing loss

Cisplatin-induced ototoxicity: The current state of …

WebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss. WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … iowa state football merchWebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological opengl draw edges of triangles

"Webhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Hearing Loss: An Under-Recognized Side Effect of Cancer Treatment

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WebSep 24, 2024 · As cisplatin is an effective treatment for cancer, researchers have focused on finding ways to counteract the associated hearing loss. Combination therapies, where a protective compound (otoprotectant) such as antioxidants, anti-inflammatories, and steroids are administered alongside cisplatin, aim at decreasing the probability of the patient ... WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients.

WebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and … WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by …

WebApr 17, 2024 · For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. Reported rates of cisplatin … WebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the …

WebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term …

WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … opengl draw grid of squaresWebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the … opengl drawing must be enabled photoshopWebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy … opengl draw framebuffer to screenWeb• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an … opengl draw meshWebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … opengl draw line c++WebJul 3, 2024 · Cisplatin-induced hearing loss is associated not only with dosage, but also with the administration protocol. Whether used in single high dose or multiple low dose, … opengl draw cylinder 3dWebCisplatin-Induced Hearing Loss Childhood Cancer Hearing Loss Patient Focused Drug Development (PFDD) Meeting The pediatric patient population with chemotherapy … opengl draw nurbs